Target
Urokinase plasminogen activator surface receptor
Ligand
BDBM222381
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
Ki
2300±300 nM
Citation
 Liu, DXu, DLiu, MKnabe, WEYuan, CZhou, DHuang, MMeroueh, SO Small Molecules Engage Hot Spots through Cooperative Binding To Inhibit a Tight Protein-Protein Interaction. Biochemistry 56:1768-1784 (2017) [PubMed]  Article 
Target
Name:
Urokinase plasminogen activator surface receptor
Synonyms:
CD_antigen=CD87 | MO3 | Monocyte activation antigen Mo3 | PLAUR | U-PAR | UPAR | UPAR_HUMAN | Urokinase plasminogen activator surface receptor | Urokinase receptor (uPAR) | Urokinase-type plasminogen activator/surface receptor
Type:
Receptor
Mol. Mass.:
36979.14
Organism:
Homo sapiens (Human)
Description:
Q03405
Residue:
335
Sequence:
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
  
Inhibitor
Name:
BDBM222381
Synonyms:
IPR-1158 (34)
Type:
Small organic molecule
Emp. Form.:
C24H15ClF3NO3
Mol. Mass.:
457.829
SMILES:
OC1=C(C(N(Cc2cc(F)cc(F)c2)C1=O)c1cccc(F)c1)C(=O)c1ccc(Cl)cc1 |t:1|
Structure:
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