Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM222432
Substrate
n/a
Meas. Tech.
Carbonic Anhydrase II Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
3.96e+3± 3.5e+2 nM
Comments
extracted
Citation
 Iqbal, S; Saleem, M; Azim, MK; Taha, M; Salar, U; Khan, KM; Perveen, S; Choudhary, MI Carbohydrazones as new class of carbonic anhydrase inhibitors: Synthesis, kinetics, and ligand docking studies. Bioorg Chem 72:89-101 (2017) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA2 | CAH2_BOVIN | Carbonic anhydrase | Carbonic anhydrase 2 | Carbonic anhydrase II | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29115.93
Organism:
Bos taurus
Description:
n/a
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIANGERQSPVDIDTKAVVQDPALKPLALVYGEATSRRMVNNGHSFNVEYDDSQDKAVLKDGPLTGTYRLVQFHFHWGSSDDQGSEHTVDRKKYAAELHLVHWNTKYGDFGTAAQQPDGLAVVGVFLKVGDANPALQKVLDALDSIKTKGKSTDFPNFDPGSLLPNVLDYWTYPGSLTTPPLLESVTWIVLKEPISVSSQQMLKFRTLNFNAEGEPELLMLANWRPAQPLKNRQVRGFPK
  
Inhibitor
Name:
BDBM222432
Synonyms:
N'',N'''-Bis[(E)-(2-bromophenyl)methylidene]carbonic dihydrazide (5)
Type:
Small organic molecule
Emp. Form.:
C15H12Br2N4O
Mol. Mass.:
424.09
SMILES:
Brc1ccccc1\C=N\NC(=O)N\N=C\c1ccccc1Br
Structure:
Search PDB for entries with ligand similarity: