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Target
DNA polymerase catalytic subunit
Ligand
BDBM222898
Substrate
n/a
Meas. Tech.
HCMV Polymerase LANCE TR-FRET Assay
pH
7.5±n/a
IC50
200±n/a nM
Comments
extracted
Citation
 Fader, L; Lepage, O; Bailey, M; Beaulieu, PL; Bilodeau, F; Carson, RJ; Giroux, A; Godbout, C; Moreau, B; Naud, J; Parisien, M; Poirier, M; Poirier, M; Surprenant, S; Thibeault, C Cytomegalovirus inhibitor compounds US Patent  US9315499 Publication Date 4/19/2016 
Target
Name:
DNA polymerase catalytic subunit
Synonyms:
DNA polymerase | DPOL_HCMVA | HFLF2 | Human herpesvirus 5 DNA polymerase | UL54
Type:
Protein
Mol. Mass.:
137111.39
Organism:
Human cytomegalovirus (HCMV strain AD169)
Description:
P08546
Residue:
1242
Sequence:
MFFNPYLSGGVTGGAVAGGRRQRSQPGSAQGSGKRPPQKQFLQIVPRGVMFDGQTGLIKHKTGRLPLMFYREIKHLLSHDMVWPCPWRETLVGRVVGPIRFHTYDQTDAVLFFDSPENVSPRYRQHLVPSGNVLRFFGATEHGYSICVNVFGQRSYFYCEYSDTDRLREVIASVGELVPEPRTPYAVSVTPATKTSIYGYGTRPVPDLQCVSISNWTMARKIGEYLLEQGFPVYEVRVDPLTRLVIDRRITTFGWCSVNRYDWRQQGRASTCDIEVDCDVSDLVAVPDDSSWPRYRCLSFDIECMSGEGGFPCAEKSDDIVIQISCVCYETGGNTAVDQGIPNGNDGRGCTSEGVIFGHSGLHLFTIGTCGQVGPDVDVYEFPSEYELLLGFMLFFQRYAPAFVTGYNINSFDLKYILTRLEYLYKVDSQRFCKLPTAQGGRFFLHSPAVGFKRQYAAAFPSASHNNPASTAATKVYIAGSVVIDMYPVCMAKTNSPNYKLNTMAELYLRQRKDDLSYKDIPRCFVANAEGRAQVGRYCLQDAVLVRDLFNTINFHYEAGAIARLAKIPLRRVIFDGQQIRIYTSLLDECACRDFILPNHYSKGTTVPETNSVAVSPNAAIISTAAVPGDAGSVAAMFQMSPPLQSAPSSQDGVSPGSGSNSSSSVGVFSVGSGSSGGVGVSNDNHGAGGTAAVSYQGATVFEPEVGYYNDPVAVFDFASLYPSIIMAHNLCYSTLLVPGGEYPVDPADVYSVTLENGVTHRFVRASVRVSVLSELLNKWVSQRRAVRECMRECQDPVRRMLLDKEQMALKVTCNAFYGFTGVVNGMMPCLPIAASITRIGRDMLERTARFIKDNFSEPCFLHNFFNQEDYVVGTREGDSEESSALPEGLETSSGGSNERRVEARVIYGDTDSVFVRFRGLTPQALVARGPSLAHYVTACLFVEPVKLEFEKVFVSLMMICKKRYIGKVEGASGLSMKGVDLVRKTACEFVKGVTRDVLSLLFEDREVSEAAVRLSRLSLDEVKKYGVPRGFWRILRRLVQARDDLYLHRVRVEDLVLSSVLSKDISLYRQSNLPHIAVIKRLAARSEELPSVGDRVFYVLTAPGVRTAPQGSSDNGDSVTAGVVSRSDAIDGTDDDADGGGVEESNRRGGEPAKKRARKPPSAVCNYEVAEDPSYVREHGVPIHADKYFEQVLKAVTNVLSPVFPGGETARKDKFLHMVLPRRLHLEPAFLPYSVKAHECC
  
Inhibitor
Name:
BDBM222898
Synonyms:
US9315499, 3008
Type:
Small organic molecule
Emp. Form.:
C26H30ClN5O4
Mol. Mass.:
512.001
SMILES:
COCCNc1ccnc2n(CC(=O)N3CC(C)(C)C3)c(=O)c(cc12)C(=O)NCc1ccc(Cl)cc1
Structure:
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