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Target
Tyrosine-protein kinase SYK [2-635]
Ligand
BDBM222942
Substrate
n/a
Meas. Tech.
Chip Based Microfluidic Mobility Shift Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
7±n/a nM
Comments
extracted
Citation
 Buehlmayer, P; Smith, AB; Thoma, G; Van Eis, M Bicyclic heteroaryl cycloalkyldiamine derivatives US Patent  US9315500 Publication Date 4/19/2016 
Target
Name:
Tyrosine-protein kinase SYK [2-635]
Synonyms:
KSYK_HUMAN | SYK | Tyrosine-protein kinase SYK | Tyrosine-protein kinase SYK (SYK)
Type:
Protein
Mol. Mass.:
71948.80
Organism:
Homo sapiens (Human)
Description:
Human Syk (2-635 aa) (UniProtKB: P43405)
Residue:
634
Sequence:
ASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM222942
Synonyms:
US9315500, 2.12
Type:
Small organic molecule
Emp. Form.:
C21H23N7O
Mol. Mass.:
389.4536
SMILES:
N[C@H]1CCCC[C@H]1Nc1cc2cn[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1
Structure:
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