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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM223001
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
6.5±n/a
Temperature
298.15±n/a K
IC50
<100±n/a nM
Comments
extracted
Citation
 Combs, AP; Yue, EW; Sparks, RB; Zhu, W 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase US Patent  US9320732 Publication Date 4/26/2016 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM223001
Synonyms:
US10034939, Example 3 | US10967060, Example 3 | US9320732, 3 | US9789094, 3
Type:
Small organic molecule
Emp. Form.:
C12H15BrFN7O4S
Mol. Mass.:
452.259
SMILES:
NS(=O)(=O)NCCCNc1nonc1C(Nc1ccc(F)c(Br)c1)=NO |w:24.26|
Structure:
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