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Target
Leukotriene C4 synthase
Ligand
BDBM223288
Substrate
LTC4
Meas. Tech.
In Vitro hLTC4 Synthase Enzyme Assay (Test B)
pH
7.5±n/a
IC50
0.248±n/a nM
Comments
extracted
Citation
 Ronn, R; Lindh, CJ; Ringberg, E; Andersson, HB; Nilsson, P; Schaal, WR; Rosenschold, MM; Nikitidis, A; Nikitidis, G; Johannesson, P; Tyrcha, C Compounds and uses  US Patent  US20160326143 Publication Date 11/10/2016 
Target
Name:
Leukotriene C4 synthase
Synonyms:
LTC4 synthase | LTC4S | LTC4S_HUMAN | Leukotriene-C(4) synthase
Type:
PROTEIN
Mol. Mass.:
16575.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_961179
Residue:
150
Sequence:
MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLRTLLPWA
  
Inhibitor
Name:
BDBM223288
Synonyms:
(1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-5-(trifluoromethyl)phenyl]amino}-3-methoxypyrazin-2-yl)carbonyl]cyclopropanecarboxylic acid | US20160326143, 63 | US9657001, 63
Type:
Small Organic Molecule
Emp. Form.:
C21H20F5N3O4
Mol. Mass.:
473.3932
SMILES:
COc1nc(cnc1C(=O)[C@H]1C[C@@H]1C(O)=O)N(CC(C)(C)F)c1cc(ccc1F)C(F)(F)F
Structure:
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Substrate
Name:
BDBM81801
Synonyms:
CAS_5283121 | LTC4 | NSC_5283121
Type:
Small organic molecule
Emp. Form.:
C30H47N3O9S
Mol. Mass.:
625.774
SMILES:
CCCCCC=CCC=CC=CC=CC(SCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O)C(O)CCCC(O)=O |w:5.4,8.7,10.9,12.11|
Structure:
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