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Target
RAC-alpha serine/threonine-protein kinase [1-123]
Ligand
BDBM223473
Substrate
n/a
Meas. Tech.
Cellular Assay
IC50
50000±n/a nM
Citation
 Mahadevan, D; Meuillet, EJ; Mash, Jr., EA; Gokhale, VM; Powis, G; Zhang, S Small molecule inhibitors of the pleckstrin homology domain and methods for using same US Patent  US9320734 Publication Date 4/26/2016 
Target
Name:
RAC-alpha serine/threonine-protein kinase [1-123]
Synonyms:
AKT1 | AKT1_HUMAN | PKB | RAC | RAC-alpha serine/threonine-protein kinase (Akt)
Type:
Enzyme
Mol. Mass.:
14664.42
Organism:
Homo sapiens (Human)
Description:
PLECKSTRIN HOMOLOGY DOMAIN RESIDUES 1-123 (PH Domain)
Residue:
123
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSG
  
Inhibitor
Name:
BDBM223473
Synonyms:
US9320734, 444
Type:
Small organic molecule
Emp. Form.:
C16H16N4O5S
Mol. Mass.:
376.387
SMILES:
COc1cc(NS(=O)(=O)c2ccc(Nc3ccco3)cc2)nc(OC)n1
Structure:
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