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Target
RAC-alpha serine/threonine-protein kinase [1-123]
Ligand
BDBM50034417
Substrate
n/a
Meas. Tech.
SPR Competitive Binding Assay
Kd
450±100 nM
Citation
 Mahadevan, D; Meuillet, EJ; Mash, Jr., EA; Gokhale, VM; Powis, G; Zhang, S Small molecule inhibitors of the pleckstrin homology domain and methods for using same US Patent  US9320734 Publication Date 4/26/2016 
Target
Name:
RAC-alpha serine/threonine-protein kinase [1-123]
Synonyms:
AKT1 | AKT1_HUMAN | PKB | RAC | RAC-alpha serine/threonine-protein kinase (Akt)
Type:
Enzyme
Mol. Mass.:
14664.42
Organism:
Homo sapiens (Human)
Description:
PLECKSTRIN HOMOLOGY DOMAIN RESIDUES 1-123 (PH Domain)
Residue:
123
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSG
  
Inhibitor
Name:
BDBM50034417
Synonyms:
4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamide | 4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide | CHEMBL286737 | US9320734, 100
Type:
Small organic molecule
Emp. Form.:
C8H8N4O2S2
Mol. Mass.:
256.305
SMILES:
Nc1ccc(cc1)S(=O)(=O)Nc1nncs1
Structure:
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