Reaction Details Report a problem with these data
Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM50416511
Substrate
BDBM223534
Meas. Tech.
NAAA Assay
pH
5±n/a
Temperature
310.15±n/a K
IC50
>100000±n/a nM
Comments
extracted
Citation
 Piomelli, D; Tarzia, G; Mor, M; Duranti, A; Tontini, A Compositions and methods of inhibiting N-acylethanolamine-hydrolyzing acid amidase US Patent  US9321743 Publication Date 4/26/2016 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | Asahl | N-acylethanolamine acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase | N-acylethanolamine-hydrolyzing acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase subunit alpha | N-acylethanolamine-hydrolyzing acid amidase subunit beta | N-acylsphingosine amidohydrolase-like | NAAA_RAT | Naaa
Type:
Enzyme
Mol. Mass.:
40306.53
Organism:
Rattus norvegicus (Rat)
Description:
Q5KTC7
Residue:
362
Sequence:
MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVSLDAAPELRWLPMLQHYDPDFVRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTSEIRGICDYLNLSLAEGVLVNLAYEASAFCTSIVAQDSQGRIYHGRNLDYPFGNALRKLTADVQFVKNGQIVFTATTFVGYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGHSPISWLIRKTLTESEDFEAAVYTLAKTPLIADVYYIVGGTSPQEGVVITRDRGGPADIWPLDPLNGAWFRVETNYDHWEPVPKRDDRRTPAIKALNATGQAHLSLETLFQVLSVFPVYNNYTIYTTVMSAAEPDKYMTMIRNPS
  
Inhibitor
Name:
BDBM50416511
Synonyms:
CHEMBL1214258 | US9321743, URB827
Type:
Small organic molecule
Emp. Form.:
C12H15NO4
Mol. Mass.:
237.2518
SMILES:
OC[C@H](NC(=O)CCc1ccccc1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM223534
Synonyms:
US9321743, Heptadecenoylethanolamide
Type:
Substrate
Emp. Form.:
C19H37NO2
Mol. Mass.:
311.5026
SMILES:
CCCCCC\C=C/CCCCCCCCC(=O)NCCO
Structure:
Search PDB for entries with ligand similarity: