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Target
Ubiquitin carboxyl-terminal hydrolase 2 [258-605]
Ligand
BDBM21680
Substrate
n/a
Meas. Tech.
Di-UB K63-2 Hydrolysis Assay
IC50
>1.00e+5±n/a nM
Citation
 Magiera, K; Tomala, M; Kubica, K; De Cesare, V; Trost, M; Zieba, BJ; Kachamakova-Trojanowska, N; Les, M; Dubin, G; Holak, TA; Skalniak, L Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a. Cell Chem Biol 24:458-470 (2017) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 2 [258-605]
Synonyms:
UBP2_HUMAN | UBP41 | USP2 | Ubiquitin-specific peptidase 2a (USP2a)
Type:
Enzyme
Mol. Mass.:
40094.16
Organism:
Homo sapiens (Human)
Description:
Hman USP2a (258-605 aa)
Residue:
348
Sequence:
MNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM
  
Inhibitor
Name:
BDBM21680
Synonyms:
(4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R,16S)-5,9,16-trihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid | (R)-4-((3R,5S,7R,8R,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oic acid | CGG | CHEMBL205596 | CHOLBAM | Cholate | Cholic Acid | cholicacid
Type:
Steroid
Emp. Form.:
C24H40O5
Mol. Mass.:
408.5714
SMILES:
[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C)[C@H](C)CCC(O)=O
Structure:
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