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TargetProtein lysine methyltransferase SUV4-20H1 (SUV4-20H1)
LigandBDBM223980
Substrate/Competitorn/a
Meas. Tech.Scintillation Proximity Assay (SPA)
pH8±0
Temperature298.15±0 K
IC50 5.9e+2± 0 nM
Citation Bromberg, KDMitchell, TRUpadhyay, AKJakob, CGJhala, MAComess, KMLasko, LMLi, CTuzon, CTDai, YLi, FEram, MSNuber, ASoni, NBManaves, VAlgire, MASweis, RFTorrent, MSchotta, GSun, CMichaelides, MRShoemaker, ARArrowsmith, CHBrown, PJSanthakumar, VMartin, ARice, JCChiang, GGVedadi, MBarsyte-Lovejoy, DPappano, WN The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat Chem Biol13:317-324 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein lysine methyltransferase SUV4-20H1 (SUV4-20H1)
Name:Protein lysine methyltransferase SUV4-20H1 (SUV4-20H1)
Synonyms:Histone-lysine N-methyltransferase SUV420H1 | KMT5B | Lysine N-methyltransferase 5B | SUV420H1 | Su(var)4-20 homolog 1 | Suppressor of variegation 4-20 homolog 1 | Suv4-20h1
Type:Enzyme
Mol. Mass.:99218.58
Organism:Homo sapiens (Human)
Description:Q4FZB7
Residue:885
Sequence:
MKWLGESKIMVVNGRRNGGKLSNDHQQNQSKLQHTGKDTLKAGKNAVERRSNRCNGNSGF
EGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTSAFPSRSSRHFSKSDSFS
HNNPVRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTSGEWARHYFLNKNKMQEKLFKE
HVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEEN
MLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPG
EEISCYYGDGFFGENNEFCECYTCERRGTGAFKSRVGLPAPAPVINSKYGLRETDKRLNR
LKKLGDSSKNSDSQSVSSNTDADTTQEKNNATSNRKSSVGVKKNSKSRTLTRQSMSRIPA
SSNSTSSKLTHINNSRVPKKLKKPAKPLLSKIKLRNHCKRLEQKNASRKLEMGNLVLKEP
KVVLYKNLPIKKDKEPEGPAQAAVASGCLTRHAAREHRQNPVRGAHSQGESSPCTYITRR
SVRTRTNLKEASDIKLEPNTLNGYKSSVTEPCPDSGEQLQPAPVLQEEELAHETAQKGEA
KCHKSDTGMSKKKSRQGKLVKQFAKIEESTPVHDSPGKDDAVPDLMGPHSDQGEHSGTVG
VPVSYTDCAPSPVGCSVVTSDSFKTKDSFRTAKSKKKRRITRYDAQLILENNSGIPKLTL
RRRHDSSSKTNDQENDGMNSSKISIKLSKDHDNDNNLYVAKLNNGFNSGSGSSSTKLKIQ
LKRDEENRGSYTEGLHENGVCCSDPLSLLESRMEVDDYSQYEEESTDDSSSSEGDEEEDD
YDDDFEDDFIPLPPAKRLRLIVGKDSIDIDISSRRREDQSLRLNA
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  Blast E-value cutoff:
BDBM223980
NameBDBM223980
Synonyms:6,7-Dichloro-N-cyclopentylquinolin-4-amine (2)
TypeSmall organic molecule
Emp. Form.C14H14Cl2N2
Mol. Mass.281.18
SMILESClc1cc2nccc(NC3CCCC3)c2cc1Cl
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a