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TargetMitogen-activated protein kinase kinase kinase 8 (MAP3K8)
LigandBDBM225230
Substrate/Competitorn/a
Meas. Tech.HMT Assay
IC50>1.0e+4± 0 nM
Citation Qi, WZhao, KGu, JHuang, YWang, YZhang, HZhang, MZhang, JYu, ZLi, LTeng, LChuai, SZhang, CZhao, MChan, HChen, ZFang, DFei, QFeng, LFeng, LGao, YGe, HGe, XLi, GLingel, ALin, YLiu, YLuo, FShi, MWang, LWang, ZYu, YZeng, JZeng, CZhang, LZhang, QZhou, SOyang, CAtadja, PLi, E An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED. Nat Chem Biol13:381-388 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)
Name:Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)
Synonyms:n/a
Type:Protein
Mol. Mass.:42506.70
Organism:Homo sapiens (Human)
Description:Human MAP3K8 truncation (30-404 aa)
Residue:375
Sequence:
MENLYASEEPAVYEPSLMTMCQDSNQNDERSKSLLLSGQEVPWLSSVRYGTVEDLLAFAN
HISNTAKHFYGQRPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAF
GKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEA
GEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLV
DFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVK
RYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALN
PPREDQPRCQSLDSA
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  Blast E-value cutoff:
BDBM225230
NameBDBM225230
Synonyms:EED226
TypeSmall organic molecule
Emp. Form.C17H15N5O3S
Mol. Mass.369.398
SMILESCS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2ccco2)n2cnnc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a