Target
Serine/threonine-protein kinase haspin [470-798]
Ligand
BDBM224011
Substrate
n/a
Meas. Tech.
Kinetic Assay with Fluorescence Anisotropy
pH
7.5±n/a
Kd
14.9±0.0 nM
Comments
extracted
Citation
 Kestav, KViht, KKonovalov, AEnkvist, EUri, ALavogina, D Slowly on, Slowly off: Bisubstrate-Analogue Conjugates of 5-Iodotubercidin and Histone H3 Peptide Targeting Protein Kinase Haspin. Chembiochem 18:790-798 (2017) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase haspin [470-798]
Synonyms:
GSG2 | HASPIN | HASP_HUMAN
Type:
Enzyme
Mol. Mass.:
37470.17
Organism:
Homo sapiens (Human)
Description:
Human haspin (470-798 aa)
Residue:
329
Sequence:
KGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK
  
Inhibitor
Name:
BDBM224011
Synonyms:
ARC-3380
Type:
Small organic molecule
Emp. Form.:
C105H163N28O24
Mol. Mass.:
2201.5893
SMILES:
CCCCCCCCCCCCCC(=O)NCCCC[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@H](CCCCNC(=O)C[C@@H](NC(=O)CCCCCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12)C([O-])=O)NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@H](C)[NH3+])C(C)O)C(=O)N[C@H](CCCCNC(=O)c1ccc(c(c1)C(O)=O)-c1c2ccc(cc2oc2cc(ccc12)=[N+](C)C)N(C)C)C(N)=O |r,wU:97.107,42.49,29.29,74.73,76.81,117.119,wD:53.96,108.112,33.38,24.24,20.20,62.62,77.77,79.80,(21.25,-5.69,;22.58,-4.92,;23.92,-5.69,;25.25,-4.92,;26.59,-5.69,;27.92,-4.92,;29.25,-5.69,;30.59,-4.92,;31.92,-5.69,;33.25,-4.92,;34.59,-5.69,;34.59,-7.23,;35.92,-8,;35.92,-9.54,;34.59,-10.31,;37.25,-10.31,;37.25,-11.85,;38.59,-12.62,;38.59,-14.16,;39.92,-14.93,;39.92,-16.47,;38.59,-17.24,;37.25,-16.47,;37.25,-14.93,;35.92,-17.24,;35.92,-18.78,;34.59,-16.47,;33.25,-17.24,;33.25,-18.78,;31.92,-16.47,;30.59,-17.24,;29.25,-16.47,;29.25,-14.93,;27.92,-17.24,;27.92,-18.78,;26.59,-19.55,;26.59,-21.09,;27.92,-21.86,;25.25,-21.86,;26.59,-16.47,;25.25,-17.24,;25.25,-18.78,;23.92,-16.47,;23.92,-14.93,;22.58,-14.16,;22.58,-12.62,;21.25,-11.85,;21.25,-10.31,;22.58,-9.54,;19.92,-9.54,;22.58,-17.24,;21.25,-16.47,;21.25,-14.93,;19.92,-17.24,;19.92,-18.78,;18.58,-19.55,;18.58,-21.09,;17.25,-21.86,;17.25,-23.4,;15.92,-24.17,;14.58,-23.4,;15.92,-25.71,;14.58,-26.48,;13.25,-25.71,;11.91,-26.48,;11.91,-28.02,;10.58,-25.71,;9.25,-26.48,;7.91,-25.71,;6.58,-26.48,;5.25,-25.71,;3.91,-26.48,;3.91,-33.15,;2.58,-33.92,;5.25,-33.92,;6.54,-33.08,;7.73,-34.05,;7.18,-35.49,;8.02,-36.78,;5.64,-35.41,;4.68,-36.61,;9.22,-33.66,;9.77,-32.22,;11.31,-32.3,;11.71,-33.79,;13.08,-34.48,;14.37,-33.65,;13.16,-36.02,;11.87,-36.86,;10.5,-36.16,;10.42,-34.62,;14.58,-28.02,;15.92,-28.79,;13.25,-28.79,;18.58,-16.47,;17.25,-17.24,;17.25,-18.78,;15.92,-16.47,;15.92,-14.93,;14.58,-14.16,;14.58,-12.62,;13.25,-11.85,;13.25,-10.31,;14.58,-9.54,;11.91,-9.54,;14.58,-17.24,;13.25,-16.47,;13.25,-14.93,;11.91,-17.24,;11.91,-18.78,;10.58,-16.47,;31.92,-14.93,;30.59,-14.16,;33.25,-14.16,;41.26,-17.24,;41.26,-18.78,;42.59,-16.47,;43.92,-17.24,;43.92,-18.78,;42.59,-19.55,;42.59,-21.09,;41.26,-21.86,;41.26,-23.4,;39.92,-24.17,;38.59,-23.4,;39.92,-25.71,;38.59,-26.48,;38.59,-28.02,;39.92,-28.79,;41.26,-28.02,;41.26,-26.48,;42.74,-28.42,;43.14,-29.91,;43.83,-27.33,;39.92,-30.33,;38.59,-31.1,;37.25,-30.33,;35.92,-31.1,;35.92,-32.64,;37.25,-33.41,;38.59,-32.64,;39.92,-33.41,;41.26,-32.64,;42.59,-33.41,;43.92,-32.64,;43.92,-31.1,;42.59,-30.33,;41.26,-31.1,;45.26,-33.41,;46.59,-32.64,;45.26,-34.95,;34.59,-33.41,;33.25,-32.64,;34.59,-34.95,;45.26,-16.47,;46.59,-17.24,;45.26,-14.93,)|
Structure:
Search PDB for entries with ligand similarity: