Reaction Details Report a problem with these data
Target
Mas-related G-protein coupled receptor member X2
Ligand
BDBM82269
Substrate
n/a
Meas. Tech.
Intracellular Calcium Mobilization Assay
pH
7.4±0
Temperature
303.15±0 K
EC50
3.2e+4±6e+3 nM
Citation
 Lansu, K; Karpiak, J; Liu, J; Huang, XP; McCorvy, JD; Kroeze, WK; Che, T; Nagase, H; Carroll, FI; Jin, J; Shoichet, BK; Roth, BL In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat Chem Biol 13:529-536 (2017) [PubMed]  Article 
Target
Name:
Mas-related G-protein coupled receptor member X2
Synonyms:
MRGPRX2 | MRGX2 | MRGX2_HUMAN | Mas-related G protein-coupled receptor X2 (MRGPRX2) | Mas-related G-protein coupled receptor member X2
Type:
GPCR
Mol. Mass.:
37104.79
Organism:
Homo sapiens (Human)
Description:
Q96LB1
Residue:
330
Sequence:
MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLALQRALQDIAEVDHSEGCFRQGTPEMSRSSLV
  
Inhibitor
Name:
BDBM82269
Synonyms:
(+)-alpha-Propoxyphene | CAS_469-62-5 | PROPOXYPHENE | Propoxyphene-d
Type:
Small organic molecule
Emp. Form.:
C22H29NO2
Mol. Mass.:
339.4712
SMILES:
CCC(=O)O[C@@](Cc1ccccc1)([C@H](C)CN(C)C)c1ccccc1
Structure:
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