Reaction Details Report a problem with these data
Target
Mas-related G-protein coupled receptor member X2
Ligand
BDBM50252954
Substrate
n/a
Meas. Tech.
PRESTO-Tango Assay
pH
7.4±0
Temperature
303.15±0 K
EC50
5.1e+3±0 nM
Citation
 Lansu, K; Karpiak, J; Liu, J; Huang, XP; McCorvy, JD; Kroeze, WK; Che, T; Nagase, H; Carroll, FI; Jin, J; Shoichet, BK; Roth, BL In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat Chem Biol 13:529-536 (2017) [PubMed]  Article 
Target
Name:
Mas-related G-protein coupled receptor member X2
Synonyms:
MRGPRX2 | MRGX2 | MRGX2_HUMAN | Mas-related G protein-coupled receptor X2 (MRGPRX2) | Mas-related G-protein coupled receptor member X2
Type:
GPCR
Mol. Mass.:
37104.79
Organism:
Homo sapiens (Human)
Description:
Q96LB1
Residue:
330
Sequence:
MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLALQRALQDIAEVDHSEGCFRQGTPEMSRSSLV
  
Inhibitor
Name:
BDBM50252954
Synonyms:
ADL-5859 | CHEMBL494480 | N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C24H28N2O3
Mol. Mass.:
392.4907
SMILES:
CCN(CC)C(=O)c1ccc(cc1)C1=CC2(CCNCC2)Oc2cccc(O)c12 |t:14|
Structure:
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