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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM225042
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
0.586±n/a nM
Citation
 Wang, H; Cee, VJ; Herberich, BJ; Jackson, CL; Lanman, BA; Nixey, T; Pettus, LH; Reed, AB; Wu, B; Wurz, R; Tasker, A Azole compounds as PIM inhibitors US Patent  US9321756 Publication Date 4/26/2016 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM225042
Synonyms:
US9321756, 4
Type:
Small organic molecule
Emp. Form.:
C19H19N7O
Mol. Mass.:
361.4005
SMILES:
Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(NC4CCCC4)n3)c2c1
Structure:
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