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Target
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
Ligand
BDBM224792
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
Temperature
298.15±n/a K
IC50
21±n/a nM
Comments
extracted
Citation
 Heine, N; Eickmeier, C; Ferrera, M; Giovannini, R; Rosenbrock, H; Schaenzle, G 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders US Patent  US9328120 Publication Date 5/3/2016 
Target
Name:
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
Synonyms:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A (PDE9A2) | Phosphodiesterase 9A2
Type:
Protein
Mol. Mass.:
61702.98
Organism:
Homo sapiens (Human)
Description:
O76083-2
Residue:
533
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
  
Inhibitor
Name:
BDBM224792
Synonyms:
US9328120, 22
Type:
Small organic molecule
Emp. Form.:
C18H18ClF2N5OS
Mol. Mass.:
425.883
SMILES:
FC1(F)CCC(CC1)n1ncc2c1nc([nH]c2=O)[C@@H]1CC[C@H]1c1csc(Cl)n1 |r|
Structure:
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