Reaction Details
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Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
Ligand
BDBM224800
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
Temperature
298.15±n/a K
IC50
304±n/a nM
Comments
extracted
Citation
Heine, N; Eickmeier, C; Ferrera, M; Giovannini, R; Rosenbrock, H; Schaenzle, G 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders US Patent US9328120 Publication Date 5/3/2016 More Info.:
Target
Name:
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
Synonyms:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A (PDE9A2) | Phosphodiesterase 9A2
Type:
Protein
Mol. Mass.:
61702.98
Organism:
Homo sapiens (Human)
Description:
O76083-2
Residue:
533
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
Inhibitor
Name:
BDBM224800
Synonyms:
US9328120, 30 (enantiomer 1) | US9328120, 31 (enantiomer 2)
Type:
Small organic molecule
Emp. Form.:
C19H21N5O2
Mol. Mass.:
351.4023
SMILES:
O=c1[nH]c(nc2n(ncc12)C1CCOCC1)C1CCC1c1ccccn1
Structure:
