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Target
Alpha-glucosidase MAL32
Ligand
BDBM225288
Substrate
n/a
Meas. Tech.
In Vitro α-Glucosidase Inhibitory Assay
pH
6.8±0
Temperature
310.15±0 K
IC50
7.31e+3± 1.5e+2 nM
Citation
 Wang, G; Wang, J; Xie, Z; Chen, M; Li, L; Peng, Y; Chen, S; Li, W; Deng, B Discovery of 3,3-di(indolyl)indolin-2-one as a novel scaffold for a-glucosidase inhibitors: In silico studies and SAR predictions Bioorg Chem 72:228-233 (2017)   
Target
Name:
Alpha-glucosidase MAL32
Synonyms:
Alpha-glucosidase MAL32 | MAL32 | MAL32_YEAST | MAL3S | Maltase | alpha-Glucosidase (α-Glucosidase) | alpha-Glucosidase (alpha-Glu) | alpha-Glucosidase (α-Glucosidase)
Type:
Hydrolase
Mol. Mass.:
68132.36
Organism:
Saccharomyces cerevisiae
Description:
Purchased from Wako Fine Chemicals Co. Ltd.
Residue:
584
Sequence:
MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCPFYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRIHEYHQELHRFMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSFTHVELGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADDSPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSFGKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFFLNESFEQGINVEQESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNFSGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
  
Inhibitor
Name:
BDBM225288
Synonyms:
1,1''-bis(2-Chlorobenzyl)-[3,3':3',3''-terindolin]-2'-one (4i)
Type:
Small organic molecule
Emp. Form.:
C38H27Cl2N3O
Mol. Mass.:
612.546
SMILES:
Clc1ccccc1Cn1cc(c2ccccc12)C1(C(=O)Nc2ccccc12)c1cn(Cc2ccccc2Cl)c2ccccc12
Structure:
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