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Target
Serine/threonine-protein kinase Chk1 [2-280]
Ligand
BDBM14605
Substrate
n/a
Meas. Tech.
33P-Radiometric_Method1
Ki
3.93±n/a nM
Citation
 D3R, DD Abbott CHK1 Kinase D3R 221:0 (2015) [PubMed] 
Target
Name:
Serine/threonine-protein kinase Chk1 [2-280]
Synonyms:
CHEK1 | CHK1 | CHK1_HUMAN | CHK1_Kinase
Type:
n/a
Mol. Mass.:
32109.16
Organism:
Homo sapiens (Human)
Description:
O14757[2-280]
Residue:
279
Sequence:
AVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTS
  
Inhibitor
Name:
BDBM14605
Synonyms:
1-(4-amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyrazin-2-yl)urea | Chk1_76 | N-pyrazinylurea Analog 7
Type:
Small organic molecule
Emp. Form.:
C13H11ClN6O2
Mol. Mass.:
318.718
SMILES:
COc1cc(N)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N
Structure:
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