Reaction Details Report a problem with these data
Target
RNA polymerase sigma factor SigB
Ligand
BDBM226117
Substrate
n/a
Meas. Tech.
Biolayer Interferometry (BLI) Assay
Kd
115±1.4 nM
Citation
 Vishwanath, S; Banerjee, S; Jamithireddy, AK; Srinivasan, N; Gopal, B; Chatterjee, J Design, Synthesis, and Experimental Validation of Peptide Ligands Targeting Mycobacterium tuberculosis s Factors. Biochemistry 56:2209-2218 (2017) [PubMed]  Article 
Target
Name:
RNA polymerase sigma factor SigB
Synonyms:
RNA polymerase sigma factor SigB (σB) | RNA polymerase sigma factor SigB (ϿB) | SIGB_MYCTU | mysB | sigB
Type:
Protein
Mol. Mass.:
36343.42
Organism:
Mycobacterium tuberculosis
Description:
P9WGI5
Residue:
323
Sequence:
MADAPTRATTSRVDSDLDAQSPAADLVRVYLNGIGKTALLNAAGEVELAKRIEAGLYAEHLLETRKRLGENRKRDLAAVVRDGEAARRHLLEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKGFKFSTYATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKREMHQHLGREATDEELAAESGIPIDKINDLLEHSRDPVSLDMPVGSEEEAPLGDFIEDAEAMSAENAVIAELLHTDIRSVLATLDEREHQVIRLRFGLDDGQPRTLDQIGKLFGLSRERVRQIERDVMSKLRHGERADRLRSYAS
  
Inhibitor
Name:
BDBM226117
Synonyms:
ELTPEERLLRAIFGEK | MT2
Type:
Small organic molecule
Emp. Form.:
C85H141N23O26
Mol. Mass.:
1901.1675
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCC(O)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: