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TargetSerine/threonine-protein kinase pim-1
LigandBDBM227173
Substrate/Competitorn/a
Meas. Tech.PIM Kinase Binding Assay
pH7.2±n/a
Temperature298.15±n/a K
Ki 0.003±n/a nM
Commentsextracted
Citation Burch, JSun, MWang, XBlackaby, WHodges, AJSharpe, A Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use US Patent US9328106 Publication Date 5/3/2016
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pim-1
Name:Serine/threonine-protein kinase pim-1
Synonyms:PIM-1 Kinase | PIM1 | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:Protein
Mol. Mass.:35681.82
Organism:Homo sapiens (Human)
Description:P11309
Residue:313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM227173
NameBDBM227173
Synonyms:US9328106, 121
TypeSmall organic molecule
Emp. Form.C21H24F2N6O2S
Mol. Mass.462.516
SMILESC[C@@H]1C[C@@H](N)CC[C@@H](O1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C |r|
Structure
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