Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM227339
Substrate
n/a
Meas. Tech.
PIM Kinase Binding Assay
pH
7.2±n/a
Temperature
298.15±n/a K
Ki
0.0131±n/a nM
Comments
extracted
Citation
 Burch, JSun, MWang, XBlackaby, WHodges, AJSharpe, A Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use US Patent  US9328106 Publication Date 5/3/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM227339
Synonyms:
US9328106, 290
Type:
Small organic molecule
Emp. Form.:
C26H27F4N5O3
Mol. Mass.:
533.5179
SMILES:
Cn1ncc(NC(=O)c2ccc(F)c(n2)-c2c(F)cc(cc2F)C2(O)CCC2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 |r,wU:32.36,34.38,wD:29.32,(-5.76,4.02,;-5.76,2.48,;-7,1.58,;-6.53,.11,;-4.99,.11,;-4.22,-1.22,;-4.22,-2.76,;-5.55,-3.53,;-2.88,-3.53,;-2.88,-5.07,;-1.55,-5.84,;-.22,-5.07,;1.12,-5.84,;-.22,-3.53,;-1.55,-2.76,;1.12,-2.76,;1.12,-1.22,;-.22,-.45,;2.45,-.45,;3.78,-1.22,;3.78,-2.76,;2.45,-3.53,;2.45,-5.07,;5.12,-.45,;5.12,1.09,;5.52,-1.94,;7,-1.54,;6.61,-.05,;-4.51,1.58,;-3.18,2.35,;-3.18,3.89,;-1.97,4.85,;-.47,4.51,;.3,5.84,;.2,3.12,;1.68,2.72,;-.47,1.73,;-1.97,1.39,)|
Structure:
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