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Target
Tyrosine-protein kinase SYK [360-635]
Ligand
BDBM227521
Substrate
n/a
Meas. Tech.
SYK Kinase Assay
Temperature
303.15±n/a K
IC50
16.3±n/a nM
Comments
extracted
Citation
 Hermann, JC; Kennedy-Smith, J; Lucas, MC; Padilla, F; Schoenfeld, RC; Wovkulich, PM Pyrrolo[2,3-B]pyrazines as SYK inhibitors US Patent  US9334278 Publication Date 5/10/2016 
Target
Name:
Tyrosine-protein kinase SYK [360-635]
Synonyms:
KSYK_HUMAN | SYK | SYK RPA purified, truncated construct of Spleen Tyrosine Kinase (aa 360-635) | Tyrosine-protein kinase SYK | recombinant human SYK(aa 360-635)
Type:
n/a
Mol. Mass.:
31987.15
Organism:
Homo sapiens (Human)
Description:
Human MetAP2 protein from a culture superatant of insect cells (sf9) infected with MetAP2 recombinant baculovirus
Residue:
276
Sequence:
PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM227521
Synonyms:
US9334278, I-10
Type:
Small organic molecule
Emp. Form.:
C16H18N6O
Mol. Mass.:
310.3537
SMILES:
CC(C)(C)NC(=O)c1c[nH]c2ncc(Nc3cccnc3)nc12
Structure:
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