Reaction Details
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Tyrosine-protein kinase SYK [360-635]
Ligand
BDBM227536
Substrate
n/a
Meas. Tech.
SYK Kinase Assay
Temperature
303.15±n/a K
IC50
71.2±n/a nM
Comments
extracted
Citation
Hermann, JC; Kennedy-Smith, J; Lucas, MC; Padilla, F; Schoenfeld, RC; Wovkulich, PM Pyrrolo[2,3-B]pyrazines as SYK inhibitors US Patent US9334278 Publication Date 5/10/2016 More Info.:
Target
Name:
Tyrosine-protein kinase SYK [360-635]
Synonyms:
KSYK_HUMAN | SYK | SYK RPA purified, truncated construct of Spleen Tyrosine Kinase (aa 360-635) | Tyrosine-protein kinase SYK | recombinant human SYK(aa 360-635)
Type:
n/a
Mol. Mass.:
31987.15
Organism:
Homo sapiens (Human)
Description:
Human MetAP2 protein from a culture superatant of insect cells (sf9) infected with MetAP2 recombinant baculovirus
Residue:
276
Sequence:
PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Inhibitor
Name:
BDBM227536
Synonyms:
US9334278, I-25
Type:
Small organic molecule
Emp. Form.:
C16H19N7O2
Mol. Mass.:
341.3678
SMILES:
COc1ncc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cn1
Structure:
