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Target
Egl nine homolog 1
Ligand
BDBM227557
Substrate
n/a
Meas. Tech.
HIF-PH Assay
pH
7.4±n/a
IC50
5200±n/a nM
Comments
extracted
Citation
 Thompson, MD; Park, JM; Arend, MP Process for making isoquinoline compounds US Patent  US9340511 Publication Date 5/17/2016 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM227557
Synonyms:
US9340511, 6 | US9708269, 6f
Type:
Small organic molecule
Emp. Form.:
C20H18N2O6
Mol. Mass.:
382.3667
SMILES:
COc1ccc(Oc2ccc3c(C)nc(C(=O)NCC(O)=O)c(O)c3c2)cc1
Structure:
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