Reaction Details Report a problem with these data
Target
Beta-lactamase OXA-1
Ligand
BDBM227599
Substrate
n/a
Meas. Tech.
Kinetic Assay
pH
7.2±n/a
Ki
380±70 nM
IC50
60±5 nM
Comments
extracted
Citation
 Che, T; Bethel, CR; Pusztai-Carey, M; Bonomo, RA; Carey, PR The different inhibition mechanisms of OXA-1 and OXA-24 ß-lactamases are determined by the stability of active site carboxylated lysine. J Biol Chem 289:6152-64 (2014) [PubMed]  Article 
Target
Name:
Beta-lactamase OXA-1
Synonyms:
BLO1_ECOLX | Beta-lactamase OXA-1 | Class D β-lactamase (OXA-1) | bla | oxa1
Type:
Enzyme
Mol. Mass.:
30882.83
Organism:
Escherichia coli (Enterobacteria)
Description:
Q83ZU9
Residue:
276
Sequence:
MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL
  
Inhibitor
Name:
BDBM227599
Synonyms:
Penem 3
Type:
Small organic molecule
Emp. Form.:
C13H10N3O4S
Mol. Mass.:
304.302
SMILES:
[O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cn2CCOCc2n1 |r,t:3|
Structure:
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