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TargetActivin receptor type-1B
LigandBDBM148372
Substrate/Competitorn/a
Meas. Tech.ALK1-6 enzymatic assays
pH7.5±n/a
IC50 1390±n/a nM
Commentsextracted
Citation Alimardanov, ACuny, GDGrewal, GSLee, AMcKew, JCMohedas, AHShen, MXu, XYu, PB BMP inhibitors and methods of use thereof US Patent US9682983 Publication Date 6/20/2017
More Info.:Get all data from this article,  Assay Method
 
Activin receptor type-1B
Name:Activin receptor type-1B
Synonyms:ACVR1B
Type:PROTEIN
Mol. Mass.:56810.99
Organism:Homo sapiens (Human)
Description:ChEMBL_587064
Residue:505
Sequence:
MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
GAARLTALRIKKTLSQLSVQEDVKI
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  Blast E-value cutoff:
BDBM148372
NameBDBM148372
Synonyms:US9682983, 33
TypeSmall organic molecule
Emp. Form.C26H25N7
Mol. Mass.435.5236
SMILESC[C@H]1CNC[C@@H](C)N1c1ccc(cn1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 |r|
Structure
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n/a