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TargetBone morphogenetic protein receptor type-1B (BMPR1B)
LigandBDBM148372
Substrate/Competitorn/a
Meas. Tech.ALK1-6 enzymatic assays
pH7.5±n/a
IC50 5280±n/a nM
Commentsextracted
Citation Alimardanov, ACuny, GDGrewal, GSLee, AMcKew, JCMohedas, AHShen, MXu, XYu, PB BMP inhibitors and methods of use thereof US Patent US9682983 Publication Date 6/20/2017
More Info.:Get all data from this article,  Assay Method
 
Bone morphogenetic protein receptor type-1B (BMPR1B)
Name:Bone morphogenetic protein receptor type-1B (BMPR1B)
Synonyms:ALK-6 | ALK6 | Bone morphogenetic protein receptor type-1B
Type:Enzyme
Mol. Mass.:56939.41
Organism:Homo sapiens (Human)
Description:O00238
Residue:502
Sequence:
MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED
DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD
GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI
EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS
WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS
MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD
TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV
EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS
RLTALRVKKTLAKMSESQDIKL
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  Blast E-value cutoff:
BDBM148372
NameBDBM148372
Synonyms:US9682983, 33
TypeSmall organic molecule
Emp. Form.C26H25N7
Mol. Mass.435.5236
SMILESC[C@H]1CNC[C@@H](C)N1c1ccc(cn1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 |r|
Structure
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n/a