Reaction Details Report a problem with these data
Target
Sodium/glucose cotransporter 1
Ligand
BDBM228500
Substrate
n/a
Meas. Tech.
SGLT1 Inhibition Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
9.2±n/a nM
Comments
extracted
Citation
 Choi, S; Kim, JE; Song, K; Lee, SH; Park, K; Seo, HJ; Kim, MJ; Park, E; Park, SO; Kong, Y; Kang, H; Son, I; Jung, ME; Cha, M; Kim, HJ; Lee, JS; Kim, M; Lee, MW; Lee, K Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives US Patent  US9340521 Publication Date 5/17/2016 
Target
Name:
Sodium/glucose cotransporter 1
Synonyms:
High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1
Type:
Protein
Mol. Mass.:
73503.78
Organism:
Homo sapiens (Human)
Description:
P13866
Residue:
664
Sequence:
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA
  
Inhibitor
Name:
BDBM228500
Synonyms:
US9340521, E052
Type:
Small organic molecule
Emp. Form.:
C23H27ClO6
Mol. Mass.:
434.91
SMILES:
Cc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3OCCCc3c2Cl)cc1 |r|
Structure:
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