Target
E3 ubiquitin-protein ligase XIAP [241-356]
Ligand
BDBM228611
Substrate
n/a
Meas. Tech.
Homogeneous Time Resolved Fluorescence (HTRF) Assay
Temperature
298.15±n/a K
IC50
3±n/a nM
Comments
extracted
Citation
 Kim, KS IAP antagonists US Patent  US9345740 Publication Date 5/24/2016 
Target
Name:
E3 ubiquitin-protein ligase XIAP [241-356]
Synonyms:
Aipa | Api3 | Birc4 | E3 ubiquitin-protein ligase XIAP | Miha | XIAP_MOUSE | Xiap
Type:
Protein
Mol. Mass.:
13010.15
Organism:
Mus musculus (Mouse)
Description:
BIR3(aa241-356, XIAP)
Residue:
116
Sequence:
SGVSSDRNFPNSTNSPRNPAMAEYEARIVTFGTWTSSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLDEKGQEYINNIHLTHSLEESLGRTAE
  
Inhibitor
Name:
BDBM228611
Synonyms:
US9345740, 8
Type:
Small organic molecule
Emp. Form.:
C57H77N9O7Si
Mol. Mass.:
1028.3629
SMILES:
CN[C@@H](C)C(=O)NC(Cc1ccc(cc1)C#CC(=O)NC1C[C@H](N(C1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC1CCCc2ccccc12)C(=O)N1C[Si](C)(C)C[C@H]1C(=O)NC1CCCc2ccccc12 |r|
Structure:
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