Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase XIAP [125-356,C202A,C213G]
Ligand
BDBM228609
Substrate
n/a
Meas. Tech.
Homogeneous Time Resolved Fluorescence (HTRF) Assay
Temperature
298.15±n/a K
IC50
205±n/a nM
Comments
extracted
Citation
 Kim, KS IAP antagonists US Patent  US9345740 Publication Date 5/24/2016 
Target
Name:
E3 ubiquitin-protein ligase XIAP [125-356,C202A,C213G]
Synonyms:
Aipa | Api3 | Birc4 | E3 ubiquitin-protein ligase XIAP (C202A)(C213G) | Miha | XIAP_MOUSE | Xiap
Type:
Protein
Mol. Mass.:
26277.76
Organism:
Mus musculus (Mouse)
Description:
BIR2-3 (125-356, C202A/C213G, XIAP)
Residue:
232
Sequence:
NPFAPDRPPETHADYLLRTGQVVDISDTIYPRNPAMCSEEARLKSFQNWPDYAHLTPRELASAGLYYTGADDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNVNVRSESGVSSDRNFPNSTNSPRNPAMAEYEARIVTFGTWTSSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLDEKGQEYINNIHLTHSLEESLGRTAE
  
Inhibitor
Name:
BDBM228609
Synonyms:
US9345740, 6
Type:
Small organic molecule
Emp. Form.:
C63H85N9O7Si
Mol. Mass.:
1108.4906
SMILES:
CN[C@@H](C)C(=O)NC(Cc1ccc(CCc2ccc(cc2)C(=O)NC2C[C@H](N(C2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC2CCCc3ccccc23)cc1)C(=O)N1C[Si](C)(C)C[C@H]1C(=O)NC1CCCc2ccccc12 |r|
Structure:
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