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Target
Tyrosine-protein kinase JAK1 [866-1154]
Ligand
BDBM228692
Substrate
n/a
Meas. Tech.
Enzymatic Assay
Temperature
298.15±n/a K
IC50
0.055±0.055 nM
Comments
extracted
Citation
 Su, W; Deng, W; Li, J; Ji, J Pyrrolopyrimidine compounds and uses thereof US Patent  US9346810 Publication Date 5/24/2016 
Target
Name:
Tyrosine-protein kinase JAK1 [866-1154]
Synonyms:
JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154)
Type:
Protein
Mol. Mass.:
33185.74
Organism:
Homo sapiens (Human)
Description:
P23458[866-1154]
Residue:
289
Sequence:
DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
  
Inhibitor
Name:
BDBM228692
Synonyms:
US10369153, Compound 219 | US9346810, 219
Type:
Small Organic Molecule
Emp. Form.:
C23H24FN7O2S
Mol. Mass.:
481.546
SMILES:
CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(NS(=O)(=O)Cc2ccccc2F)cn1
Structure:
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