Reaction Details Report a problem with these data
Target
Prokineticin receptor 2
Ligand
BDBM121129
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
102±0.0 nM
Comments
extracted
Citation
 Chen, DN; Ma, YT; Liu, H; Zhou, QY; Li, JD Functional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in trafficking. J Biol Chem 289:15518-26 (2014) [PubMed]  Article 
Target
Name:
Prokineticin receptor 2
Synonyms:
G-protein coupled receptor 73-like 1 | GPR73L1 | GPR73b | GPRg2 | PKR2 | PKR2_HUMAN | PROKR2 | Prokineticin Receptor 2 (PKR2)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44009.48
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed on membranes from CHO cells stably transfected with PKR2.
Residue:
384
Sequence:
MAAQNGNTSFTPNFNPPQDHASSLSFNFSYGDYDLPMDEDEDMTKTRTFFAAKIVIGIALAGIMLVCGIGNFVFIAALTRYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFATETVLFIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYFKKMMLLHWRPSQRGSKSSADLDLRTNGVPTTEEVDCIRLK
  
Inhibitor
Name:
BDBM121129
Synonyms:
A457 | US8722896, (+/-)-1-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Type:
Small organic molecule
Emp. Form.:
C26H33ClN2O3
Mol. Mass.:
457.005
SMILES:
CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2ccccc2)C1
Structure:
Search PDB for entries with ligand similarity: