Target
Tyrosine-protein kinase JAK2
Ligand
BDBM230145
Substrate
n/a
Meas. Tech.
Jak2 Tyrosine Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
200±n/a nM
Comments
extracted
Citation
 Batt, DGBertrand, MBDelucca, GGalella, MAKo, SSLangevine, CMLiu, QShi, QSrivastava, ASTino, JAWatterson, SH Substituted tetrahydrocarbazole and carbazole carboxamide compounds US Patent  US9334290 Publication Date 5/10/2016 
Target
Name:
Tyrosine-protein kinase JAK2
Synonyms:
JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase)
Type:
Protein
Mol. Mass.:
130684.68
Organism:
Homo sapiens (Human)
Description:
O60674
Residue:
1132
Sequence:
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM230145
Synonyms:
US10106559, Comparative Example 76 | US10435415, Example Comparative 76 | US9334290, Comparative Example 76 | US9714234, Comparative Ex. 35 | US9850258, Example Comparative 76
Type:
Small organic molecule
Emp. Form.:
C31H27N5O3
Mol. Mass.:
517.5778
SMILES:
Cc1nc(C(N)=O)c2[nH]c3cc(ccc3c2c1-c1cccc(c1C)-n1cnc2ccccc2c1=O)C(C)(C)O |(3.34,1.54,;1.8,1.54,;1.8,3.08,;.47,3.85,;.47,5.39,;1.8,6.16,;-.86,6.16,;-.86,3.08,;-2.33,3.56,;-3.23,2.31,;-4.77,2.15,;-5.39,.74,;-4.49,-.5,;-2.95,-.34,;-2.33,1.06,;-.86,1.54,;.47,.77,;.47,-.77,;-.86,-1.54,;-.86,-3.08,;.47,-3.85,;1.8,-3.08,;1.8,-1.54,;3.14,-.77,;3.14,-3.85,;3.14,-5.39,;4.47,-6.16,;5.8,-5.39,;7.14,-6.16,;8.47,-5.39,;8.47,-3.85,;7.14,-3.08,;5.8,-3.85,;4.47,-3.08,;4.47,-1.54,;-6.93,.74,;-7.7,-.59,;-8.47,.74,;-7.7,2.08,)|
Structure:
Search PDB for entries with ligand similarity: