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Target
Neutrophil elastase
Ligand
BDBM230298
Substrate
n/a
Meas. Tech.
Human Neutrophil Elastase Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
97±n/a nM
Comments
extracted
Citation
 Oost, T; Fiegen, D; Gnamm, C; Handschuh, S; Peters, S; Roth, GJ Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity US Patent  US9340507 Publication Date 5/17/2016 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM230298
Synonyms:
US9340507, 3.2
Type:
Small organic molecule
Emp. Form.:
C23H22F3N3O2
Mol. Mass.:
429.4349
SMILES:
CC(C)n1cc(C(=O)NCc2ccncc2)c(=O)c(-c2cccc(c2)C(F)(F)F)c1C
Structure:
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