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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM231591
Substrate
n/a
Meas. Tech.
Biotin Assay
IC50
1500±n/a nM
Citation
 Cardone, MH; Kolodziej, AF; Richard, D Compositions and methods useful for treating diseases US Patent  US9345700 Publication Date 5/24/2016 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM231591
Synonyms:
US9345700, 26
Type:
Small organic molecule
Emp. Form.:
C26H17N5O2
Mol. Mass.:
431.4455
SMILES:
O=C(Nc1cccnc1)c1cc(nc2ccc(cc12)-c1ccc2[nH]cnc2c1)-c1ccco1
Structure:
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