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Target
Nuclear receptor ROR-gamma [258-518]
Ligand
BDBM231227
Substrate
n/a
Meas. Tech.
ThermoFluor® Assay
pH
7±n/a
Temperature
274.15±n/a K
Kd
230±n/a nM
Comments
extracted
Citation
 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Alkyl linked quinolinyl modulators of RORγt US Patent  US9346782 Publication Date 5/24/2016 
Target
Name:
Nuclear receptor ROR-gamma [258-518]
Synonyms:
NR1F3 | RORC | RORG | RORG_HUMAN | RZRG | Retinoic acid-related nuclear receptor gamma t (RORγt)
Type:
Enzyme
Mol. Mass.:
32598.62
Organism:
Artificial Sequence
Description:
Artificial Sequence Construct used in the Thermofluor Assay (Seq No: 4)
Residue:
283
Sequence:
MAHHHHHHAGGAENLYFQGAMDSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM231227
Synonyms:
US9346782, 7a | US9346782, 7b | US9346782, 7c
Type:
Small organic molecule
Emp. Form.:
C26H22ClF3N2O3
Mol. Mass.:
502.913
SMILES:
COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)C1CN(C1)C(C)=O
Structure:
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