Reaction Details Report a problem with these data
Target
Troponin C, slow skeletal and cardiac muscles [4-85]
Ligand
BDBM231693
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
7±n/a
Temperature
287.15±n/a K
Kd
1.57e+4± 2.9e+3 nM
Comments
extracted
Citation
 Yu, J; Wang, S; Yu, J; Liu, C; Xu, F; Wang, S; Yi, Y; Yin, Y Structure-based rational design of self-inhibitory peptides to disrupt the intermolecular interaction between the troponin subunits C and I in neuropathic pain. Bioorg Chem 73:10-15 (2017) [PubMed]  Article 
Target
Name:
Troponin C, slow skeletal and cardiac muscles [4-85]
Synonyms:
TNNC | TNNC1 | TNNC1_HUMAN | Troponin C (TnC)
Type:
Protein
Mol. Mass.:
9243.35
Organism:
Homo sapiens (Human)
Description:
Human TnC N-terminal domain (4-85 aa)
Residue:
82
Sequence:
IYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCM
  
Inhibitor
Name:
BDBM231693
Synonyms:
ADAMMQALLGAR | pΔn2Δc4 peptide
Type:
Small organic molecule
Emp. Form.:
C51H90N16O16S2
Mol. Mass.:
1247.488
SMILES:
CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r|
Structure:
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