Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM232393
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay (FPA)
Temperature
298.15±n/a K
IC50
860±n/a nM
Comments
extracted
Citation
 Borzilleri, RM; Cai, Z; Tebben, AJ; Perez, HL; Zhang, L; Schroeder, GM; Wei, DD Substituted sulfonamides useful as antiapoptotic Bcl inhibitors US Patent  US9346795 Publication Date 5/24/2016 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM232393
Synonyms:
US9346795, 38
Type:
Small organic molecule
Emp. Form.:
C47H57ClN6O5S
Mol. Mass.:
853.511
SMILES:
CCCCN(CCCC)C(=O)c1nn(c(C)c1Cl)-c1ccc(CNS(=O)(=O)c2ccc3ccc(OCCC4CCCN4C)cc3c2)cc1C(=O)N1CCc2ccccc2C1
Structure:
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