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Target
Bcl-2-like protein 1
Ligand
BDBM232427
Substrate
n/a
Meas. Tech.
Fluorescence Resonance Energy Transfer Assay (FRET)
Temperature
298.15±n/a K
IC50
30±n/a nM
Comments
extracted
Citation
 Borzilleri, RM; Cai, Z; Tebben, AJ; Perez, HL; Zhang, L; Schroeder, GM; Wei, DD Substituted sulfonamides useful as antiapoptotic Bcl inhibitors US Patent  US9346795 Publication Date 5/24/2016 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM232427
Synonyms:
US9346795, 192
Type:
Small organic molecule
Emp. Form.:
C38H40ClN5O5S
Mol. Mass.:
714.273
SMILES:
CCCN(CCC)c1nn(c(C)c1Cl)-c1ccc(cc1C(=O)N1Cc2ccccc2C[C@H]1CO)C(=O)NS(=O)(=O)c1ccc2ccccc2c1
Structure:
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