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Target
3-hydroxyacyl-CoA dehydrogenase type-2
Ligand
BDBM232924
Substrate
n/a
Meas. Tech.
ABAD Enzymatic Activity Assay
pH
7.3±n/a
Temperature
298.15±n/a K
Ki
91100±n/a nM
IC50
335000±n/a nM
Kd
954±n/a nM
Comments
extracted
Citation
 Yan, S; Valasani, KR Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease US Patent  US9346839 Publication Date 5/24/2016 
Target
Name:
3-hydroxyacyl-CoA dehydrogenase type-2
Synonyms:
Amyloid Binding Alcohol Dehydrogenase | ERAB | HADH2 | HCD2_HUMAN | HSD17B10 | MRPP2 | SCHAD | SDR5C1 | XH98G2
Type:
Enyzme
Mol. Mass.:
26924.79
Organism:
Homo sapiens (Human)
Description:
Q99714
Residue:
261
Sequence:
MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVIRLDGAIRMQP
  
Inhibitor
Name:
BDBM232924
Synonyms:
US9346839, 5 | US9738668, Compound 5
Type:
Small organic molecule
Emp. Form.:
C18H18FN2O6PS
Mol. Mass.:
440.382
SMILES:
COC(=O)c1cc(ccc1O)[C@H](Nc1nc2cc(F)ccc2s1)P(=O)(OC)OC |r|
Structure:
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