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Target
Voltage-dependent calcium channel gamma-2 subunit
Ligand
BDBM292064
Substrate
n/a
Meas. Tech.
Biological Assays Calcium Flux Assay
pH
7.4±n/a
IC50
63.1±n/a nM
Comments
extracted
Citation
 Ameriks, MK; Laforteza, BN; Savall, BM; Wade, WS; Meyer, ST; Gyuris, M 3-aryl-2H-pyrazolo[4,3-b]pyridine compounds and their use as AMPA receptor modulators US Patent  US10100045 Publication Date 10/16/2018 
Target
Name:
Voltage-dependent calcium channel gamma-2 subunit
Synonyms:
CACNG2 | CCG2_HUMAN | Neuronal voltage-gated calcium channel gamma-2 subunit | TARP gamma-2 | Transmembrane AMPAR regulatory protein gamma-2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35977.54
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
323
Sequence:
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV
  
Inhibitor
Name:
BDBM292064
Synonyms:
3-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-pyrazolo[4,3-b]pyridine; and | US10100045, Example 39
Type:
Small organic molecule
Emp. Form.:
C16H14ClN5
Mol. Mass.:
311.769
SMILES:
CC(C)n1nc2cccnc2c1-c1cc(Cl)c2[nH]ncc2c1
Structure:
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