Reaction Details
Report a problem with these data
Report a problem with these dataTarget
cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM233041
Substrate
n/a
Meas. Tech.
5α-Reductase Activity Assay
pH
6.5±0
Temperature
310.15±0 K
IC50
70±0.0 nM
Citation
Bratoeff, E; Zambrano, A; Heuze, I; Palacios, A; Ramírez, D; Cabeza, M Synthesis and biological activity of progesterone derivatives as 5alpha-reductase inhibitors, and their effect on hamster prostate weight. J Enzyme Inhib Med Chem 25:306-11 (2010) [PubMed] Article More Info.:
Target
Name:
cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
5-alpha-Reductase (5α-Reductase)
Type:
Enzyme
Mol. Mass.:
24182.16
Organism:
Homo sapiens (Human)
Description:
EC 1.3.99.5; B7Z4L2
Residue:
212
Sequence:
MEHAAQPWRWQRRRGWRRSACWPRSPTCSAPWAARSSRGIVRRTQCTAATRCPATGSECRRGPPGWCRSCPRWPCRSTSTPASPPRVSAARPTASSWPCSSSTTGIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
Inhibitor
Name:
BDBM233041
Synonyms:
3,20-Dioxopregna-4,6-dien-17α-yl acetate (7)
Type:
Small organic molecule
Emp. Form.:
C23H30O4
Mol. Mass.:
370.4819
SMILES:
CC(=O)O[C@@]1(CCC2C3C=CC4=CC(=O)CC[C@]4(C)C3CC[C@]12C)C(C)=O |r,c:9,t:11|
Structure:
