Reaction Details
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cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM233042
Substrate
n/a
Meas. Tech.
5α-Reductase Activity Assay
pH
6.5±0
Temperature
310.15±0 K
IC50
22±0.0 nM
Citation
Bratoeff, E; Zambrano, A; Heuze, I; Palacios, A; Ramírez, D; Cabeza, M Synthesis and biological activity of progesterone derivatives as 5alpha-reductase inhibitors, and their effect on hamster prostate weight. J Enzyme Inhib Med Chem 25:306-11 (2010) [PubMed] Article More Info.:
Target
Name:
cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
5-alpha-Reductase (5α-Reductase)
Type:
Enzyme
Mol. Mass.:
24182.16
Organism:
Homo sapiens (Human)
Description:
EC 1.3.99.5; B7Z4L2
Residue:
212
Sequence:
MEHAAQPWRWQRRRGWRRSACWPRSPTCSAPWAARSSRGIVRRTQCTAATRCPATGSECRRGPPGWCRSCPRWPCRSTSTPASPPRVSAARPTASSWPCSSSTTGIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
Inhibitor
Name:
BDBM233042
Synonyms:
3,20-Dioxo-6,7-epoxypregn-4-ene-7α-yl acetate (8)
Type:
Small organic molecule
Emp. Form.:
C23H30O5
Mol. Mass.:
386.4813
SMILES:
CC(=O)O[C@@]1(CCC2C3[C@@H]4O[C@@H]4C4=CC(=O)CC[C@]4(C)C3CC[C@]12C)C(C)=O |r,t:13|
Structure:
