Reaction Details Report a problem with these data
Target
Ras-like protein 2
Ligand
BDBM233128
Substrate
n/a
Meas. Tech.
Fluorescence-Based PFTase Inhibition Assay
pH
7.5±0
Temperature
303.15±0 K
IC50
9.0e+4±n/a nM
Citation
 Pinel, B; Dubois, J; Séraphin, D; Richomme, P Semisynthesis of alpha-methyl-gamma-lactones and in vitro evaluation of their activity on protein farnesyltransferase. J Enzyme Inhib Med Chem 25:172-9 (2010) [PubMed]  Article 
Target
Name:
Ras-like protein 2
Synonyms:
ASC1 | CTN5 | GLC5 | Protein farnesyltransferase (PFTase) | RAS2 | RAS2_YEAST
Type:
Enzyme
Mol. Mass.:
34705.81
Organism:
Saccharomyces cerevisiae (Baker's yeast)
Description:
P01120
Residue:
322
Sequence:
MPLNKSNIREYKLVVVGGGGVGKSALTIQLTQSHFVDEYDPTIEDSYRKQVVIDDEVSILDILDTAGQEEYSAMREQYMRNGEGFLLVYSITSKSSLDELMTYYQQILRVKDTDYVPIVVVGNKSDLENEKQVSYQDGLNMAKQMNAPFLETSAKQAINVEEAFYTLARLVRDEGGKYNKTLTENDNSKQTSQDTKGSGANSVPRNSGGHRKMSNAANGKNVNSSTTVVNARNASIESKTGLAGNQATNGKTQTDRTNIDNSTGQAGQANAQSANTVNNRVNNNSKAGQVSNAKQARKQQAAPGGNTSEASKSGSGGCCIIS
  
Inhibitor
Name:
BDBM233128
Synonyms:
11β,13-Dihydroxanthatin-1,5α-epoxide (11)
Type:
Small organic molecule
Emp. Form.:
C15H20O4
Mol. Mass.:
264.3169
SMILES:
C[C@@H]1[C@H]2C[C@H]3O[C@@]3(\C=C\C(C)=O)[C@@H](C)C[C@@H]2OC1=O |r|
Structure:
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