Target
Ras-like protein 2
Ligand
BDBM233135
Substrate
n/a
Meas. Tech.
Fluorescence-Based PFTase Inhibition Assay
pH
7.5±0
Temperature
303.15±0 K
IC50
1.88e+4±n/a nM
Citation
 Pinel, BDubois, JSéraphin, DRichomme, P Semisynthesis of alpha-methyl-gamma-lactones and in vitro evaluation of their activity on protein farnesyltransferase. J Enzyme Inhib Med Chem 25:172-9 (2010) [PubMed]  Article 
Target
Name:
Ras-like protein 2
Synonyms:
ASC1 | CTN5 | GLC5 | Protein farnesyltransferase (PFTase) | RAS2 | RAS2_YEAST
Type:
Enzyme
Mol. Mass.:
34705.81
Organism:
Saccharomyces cerevisiae (Baker's yeast)
Description:
P01120
Residue:
322
Sequence:
MPLNKSNIREYKLVVVGGGGVGKSALTIQLTQSHFVDEYDPTIEDSYRKQVVIDDEVSILDILDTAGQEEYSAMREQYMRNGEGFLLVYSITSKSSLDELMTYYQQILRVKDTDYVPIVVVGNKSDLENEKQVSYQDGLNMAKQMNAPFLETSAKQAINVEEAFYTLARLVRDEGGKYNKTLTENDNSKQTSQDTKGSGANSVPRNSGGHRKMSNAANGKNVNSSTTVVNARNASIESKTGLAGNQATNGKTQTDRTNIDNSTGQAGQANAQSANTVNNRVNNNSKAGQVSNAKQARKQQAAPGGNTSEASKSGSGGCCIIS
  
Inhibitor
Name:
BDBM233135
Synonyms:
6-O-angeloylprenolin
Type:
Small organic molecule
Emp. Form.:
C20H26O5
Mol. Mass.:
346.4174
SMILES:
C\C=C(\C)C(=O)O[C@H]1[C@@H]2[C@@H](C[C@@H](C)[C@@H]3C=CC(=O)[C@@]13C)OC(=O)[C@H]2C |r,c:14|
Structure:
Search PDB for entries with ligand similarity: