Reaction Details
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Serine/threonine-protein kinase pim-3
Ligand
BDBM161971
Substrate
n/a
Meas. Tech.
PIM-3 Biochemical Assay
IC50
550±n/a nM
Citation
Pastor Fernández, J; Ramos Lima, FJ; Hernandez Higueras, AI; Martínez González, S; Martín Hernando, JI; Saluste, CP; Gonzalez Cantalapiedra, E; Blanco Aparicio, C; Rodríguez Hergueta, A; Garcia Collazo, AM; Salgado Serrano, A; Noya Marino, B Tricyclic compounds for use as kinase inhibitors US Patent US9682991 Publication Date 6/20/2017 More Info.:
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
Inhibitor
Name:
BDBM161971
Synonyms:
US9682991, 20
Type:
Small organic molecule
Emp. Form.:
C21H23F3N6O3
Mol. Mass.:
464.4409
SMILES:
CN1CCOc2c(N[C@H]3CC[C@H](O)CC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1 |r,wU:11.11,wD:8.7,(.39,6.55,;-.94,5.78,;-2.27,6.55,;-3.61,5.78,;-3.61,4.24,;-2.27,3.47,;-2.27,1.93,;-3.61,1.16,;-3.61,-.38,;-4.94,-1.15,;-4.94,-2.69,;-3.61,-3.46,;-3.61,-5,;-2.27,-2.69,;-2.27,-1.15,;-.94,1.16,;.39,1.93,;1.86,1.45,;2.76,2.7,;1.86,3.94,;.39,3.47,;-.94,4.24,;2.63,.12,;4.17,.12,;4.94,-1.21,;4.17,-2.55,;2.63,-2.55,;1.86,-3.88,;2.63,-5.22,;3.4,-6.55,;4.17,-5.22,;1.86,-6.55,;1.86,-1.21,)|
Structure:
