Reaction Details
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Serine/threonine-protein kinase pim-1
Ligand
BDBM161996
Substrate
n/a
Meas. Tech.
PIM-1 Biochemical Assay
IC50
550±n/a nM
Citation
Pastor Fernández, J; Ramos Lima, FJ; Hernandez Higueras, AI; Martínez González, S; Martín Hernando, JI; Saluste, CP; Gonzalez Cantalapiedra, E; Blanco Aparicio, C; Rodríguez Hergueta, A; Garcia Collazo, AM; Salgado Serrano, A; Noya Marino, B Tricyclic compounds for use as kinase inhibitors US Patent US9682991 Publication Date 6/20/2017 More Info.:
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
Inhibitor
Name:
BDBM161996
Synonyms:
US9682991, 46
Type:
Small organic molecule
Emp. Form.:
C20H22F3N7O2
Mol. Mass.:
449.4296
SMILES:
CN1CCOc2c(nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1)N1CCC(N)CC1
Structure:
