Reaction Details
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Serine/threonine-protein kinase pim-1
Ligand
BDBM162015
Substrate
n/a
Meas. Tech.
PIM-1 Biochemical Assay
IC50
<100±n/a nM
Citation
Pastor Fernández, J; Ramos Lima, FJ; Hernandez Higueras, AI; Martínez González, S; Martín Hernando, JI; Saluste, CP; Gonzalez Cantalapiedra, E; Blanco Aparicio, C; Rodríguez Hergueta, A; Garcia Collazo, AM; Salgado Serrano, A; Noya Marino, B Tricyclic compounds for use as kinase inhibitors US Patent US9682991 Publication Date 6/20/2017 More Info.:
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
Inhibitor
Name:
BDBM162015
Synonyms:
US9682991, 71
Type:
Small organic molecule
Emp. Form.:
C21H24F3N7O2
Mol. Mass.:
463.4562
SMILES:
CN1CCOc2c1c(N[C@H]1CC[C@H](N)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1 |r,wU:9.9,wD:12.13,(-6.57,2.69,;-5.24,3.47,;-5.24,5,;-3.91,5.78,;-2.57,5,;-2.57,3.47,;-3.91,2.69,;-3.91,1.15,;-5.24,.38,;-5.24,-1.15,;-3.91,-1.93,;-3.91,-3.47,;-5.24,-4.23,;-5.24,-5.78,;-6.57,-3.47,;-6.57,-1.93,;-2.57,.38,;-1.24,1.15,;.23,.68,;1.13,1.93,;.23,3.17,;-1.24,2.69,;.62,-.81,;-.46,-1.9,;-.07,-3.38,;1.42,-3.78,;2.51,-2.69,;4,-3.09,;5.09,-2,;6.57,-2.4,;4.69,-.52,;5.86,-3.34,;2.11,-1.21,)|
Structure:
